2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine

Base Information

Chemical Name:2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine
CAS No.:1366660-82-3
Molecular Formula:C₂₀H₁₇F₃N₈O₂
Molecular Weight:458.403
Hs Code.:

Synonyms:2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine

There total 4 articles about 2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1366660-86-7
[5-(3-{4-amino-6-[methyl(phenyl)amino]-1,3,5-triazin-2-yl}-1,2,4-oxadiazol-5-yl)pyridin-2-yl]methanol

: 1366660-82-3
2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 72h; Inert atmosphere;

Reference yield:

: 17874-76-9
6-(methoxycarbonyl)nicotinic acid

: 1366660-82-3
2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 - 100 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 40 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 72 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 1366663-05-9
4-amino-N-hydroxy-6-[methyl(phenyl)amino]-1,3,5-triazine-2-carboximidamide

: 1366660-82-3
2-N-methyl-2-N-phenyl-6-(5-{6-[(2,2,2-trifluoroethoxy)methyl]pyridin-3-yl}-1,2,4-oxadiazol-3-yl)-1,3,5-triazine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 - 100 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 40 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 72 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; mineral oil;