ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate

Base Information

Chemical Name:ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate
CAS No.:227467-74-5
Molecular Formula:C₂₁H₂₆Cl₂N₂O₄
Molecular Weight:441.354
Hs Code.:

Synonyms:ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate

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Chemical Property of ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate

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Technology Process of ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate

There total 4 articles about ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 552-85-2,771-91-5,1926-72-3,13104-32-0,37692-93-6,52446-53-4,62928-85-2,62928-86-3,73027-12-0
4-((1R,2S)-2-amino-1-hydroxypropyl)phenol

: 227467-61-0
ethyl N-[4-(2-bromoethyl)-2,6-dichlorophenyl]aminoacetate

: 227467-74-5
ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 70 ℃; for 7h;
DOI:10.1021/jm000455z

Reference yield:

: 227467-47-2
ethyl N-[4-(2-hydroxyethyl)phenyl]aminoacetate

: 227467-74-5
ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: t-butyl hypochlorite; conc. aq. HCl / acetonitrile / 1 h

2: 89 percent / Ph₃P; CBr₄ / CH₂Cl₂ / 1 h

3: 64 percent / N,N-diisopropylethylamine / dimethylformamide / 7 h / 70 °C

With hydrogenchloride; tert-butylhypochlorite; carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm000455z

Reference yield:

: 344285-86-5
ethyl N-[2,6-dichloro-4-(2-hydroxyethyl)phenyl]aminoacetate

: 227467-74-5
ethyl N-[2,6-dichloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenyl]aminoacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Ph₃P; CBr₄ / CH₂Cl₂ / 1 h

2: 64 percent / N,N-diisopropylethylamine / dimethylformamide / 7 h / 70 °C

With carbon tetrabromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000455z