N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide

Base Information

Chemical Name:N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide
CAS No.:1326777-03-0
Molecular Formula:C₂₄H₃₅NO₂Si
Molecular Weight:397.633
Hs Code.:

Synonyms:N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide

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Technology Process of N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide

There total 6 articles about N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1326776-83-3
(S)-(E)-N-(5-((tert-butyldiphenylsilyl)oxy)-4-methylpent-3-en-2-yl)acetamide

: 1326777-03-0
N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide

Guidance literature:: With hydrogen; In dichloromethane; at 25 ℃; for 16h; under 37503.8 Torr; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo201215c

Reference yield:

: 109986-65-4
methyl (2E,4S)-4-(tert-butoxycarbonylamino)-2-methyl-2-pentenoate

: 1326777-03-0
N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 5 h / -50 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: 1H-imidazole / dichloromethane / 24 h / 25 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 4 h / 25 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: pyridine / dichloromethane / 1 h / 25 °C / Inert atmosphere

5.1: hydrogen / dichloromethane / 16 h / 25 °C / 37503.8 Torr / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; hydrogen; diisobutylaluminium hydride; In 1,4-dioxane; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo201215c

Reference yield:

: 109986-67-6
-(4-hydroxy-1,3-dimethyl-2-butenyl)carbamic acid tert-butyl ester

: 1326777-03-0
N-((2S,4R)-5-((tert-butyldiphenylsilyl)oxy)-4-methylpentan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 24 h / 25 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; diethyl ether / 4 h / 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: pyridine / dichloromethane / 1 h / 25 °C / Inert atmosphere

4.1: hydrogen / dichloromethane / 16 h / 25 °C / 37503.8 Torr / Inert atmosphere

With pyridine; 1H-imidazole; hydrogenchloride; hydrogen; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/jo201215c