6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one

Base Information

• Chemical Name: 6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one
• CAS No.: 1073282-36-6
• Molecular Formula: C₁₈H₁₂ClN₃O₃S
• Molecular Weight: 385.831
• Mol file: 1073282-36-6.mol

Synonyms:6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one

Chemical Property of 6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one

There total 1 articles about 6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(6-(4-Chlorophenyl)-4-oxothieno[3,2-d][1,2,3]triazin-3(4H)-yl)-2-methoxyphenyl acetate (1073282-35-5) → 6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one (1073282-36-6)

Guidance literature:

With hydrogenchloride; water; In methanol; dichloromethane; acetic acid methyl ester; for 3h;

Reference yield: 94.0%

6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one (1073282-36-6) + chloroacetone (78-95-5) → 6-(4-Chlorophenyl)-3-(3-methoxy-4-(2-oxopropoxy)phenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one (1073282-21-9)

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 2.3h;

Reference yield: 89.0%

6-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one (1073282-36-6) + 2-cyclopropyl-2-oxoethyl 4-methylbenzenesulfonate (81447-28-1) → 6-(4-Chlorophenyl)-3-(4-(2-cyclopropyl-2-oxoethoxy)-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one (1073282-37-7)

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 3.3h;

upstream raw materials:

4-(6-(4-Chlorophenyl)-4-oxothieno[3,2-d][1,2,3]triazin-3(4H)-yl)-2-methoxyphenyl acetate

Downstream raw materials:

6-(4-Chlorophenyl)-3-(3-methoxy-4-(2-oxopropoxy)phenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one

C₂₅H₂₄ClN₃O₅S

6-(4-Chlorophenyl)-3-(3-methoxy-4-(3,3,3-trifluoro-2-hydroxypropoxy)phenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one

6-(4-Chlorophenyl)-3-(4-(2-cyclopropyl-2-oxoethoxy)-3-methoxyphenyl)thieno[3,2-d][1,2,3]triazin-4(3H)-one