3-AMINO-5-CYCLOPENTYL-2H-PYRAZOLE

Base Information

• Chemical Name: 3-AMINO-5-CYCLOPENTYL-2H-PYRAZOLE
• CAS No.: 264209-16-7
• Molecular Formula: C8H13 N3
• Molecular Weight: 151.211
• Hs Code.: 2933199090
• Mol file: 264209-16-7.mol

Synonyms:3-Amino-5-cyclopentylpyrazole;3-Cyclopentyl-1H-pyrazole-5-amine; 3-Cyclopentyl-5-amino-1H-pyrazole;5-Cyclopentyl-2H-pyrazol-3-ylamine

Chemical Property of 3-AMINO-5-CYCLOPENTYL-2H-PYRAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.616
• Boiling Point: 373.5°Cat760mmHg
• PKA: 15.76±0.10(Predicted)
• Flash Point: 207.5°C
• PSA: 54.70000
• Density: 1.193g/cm³
• LogP: 2.23070
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Cyclopentyl-1H-pyrazol-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-5-CYCLOPENTYL-2H-PYRAZOLE

There total 3 articles about 3-AMINO-5-CYCLOPENTYL-2H-PYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-cyclopentyl-3-oxopropanenitrile (95882-33-0) → 5-cyclopentyl-1H-pyrazol-3-ylamine (264209-16-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 4h;

Reference yield: 67.0%

3-cyclopentyl-3-oxopropanenitrile (95882-33-0) → 5-cyclopentyl-2H-pyrazol-3-ylamine (264209-16-7)

Guidance literature:

With hydrazine; In ethanol; Heating / reflux;

Reference yield:

→ 5-cyclopentyl-2H-pyrazol-3-ylamine (264209-16-7)

Guidance literature:

upstream raw materials:

3-cyclopentyl-3-oxopropanenitrile

Downstream raw materials:

2-chloro-N-(5-cyclopentyl-1H-pyrazol-3-yl)pyrimidin-4-amine

Refernces

• 1、 -. "MODULATORS OF MYC FAMILY PROTO-ONCOGENE PROTEIN". Paragraph 00125. . Retrieved 2020/09/08.
• 2、 Rana, Sandeep,Sonawane, Yogesh A.,Taylor, Margaret A.,Kizhake, Smitha,Zahid, Muhammad,Natarajan, Amarnath. "Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy". supporting information. p. 3736 - 3740. Retrieved 2018/10/24.