2-(3-Azidophenyl)acetic acid

Base Information

• Chemical Name: 2-(3-Azidophenyl)acetic acid
• CAS No.: 83528-01-2
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.162
• European Community (EC) Number: 961-545-6
• Mol file: 83528-01-2.mol

Synonyms:2-(3-azidophenyl)acetic acid;83528-01-2;EN300-8207337

Chemical Property of 2-(3-Azidophenyl)acetic acid

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 177.053826475
• Heavy Atom Count: 13
• Complexity: 236

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)N=[N+]=[N-])CC(=O)O

Technology Process of 2-(3-Azidophenyl)acetic acid

There total 1 articles about 2-(3-Azidophenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-amino phenylacetic acid (14338-36-4) → 3-azidophenylacetic acid (83528-01-2)

Guidance literature:

3-amino phenylacetic acid; With hydrogenchloride; sulfuric acid; sodium nitrite; at 0 ℃; for 0.5h;

With sodium azide; at 0 ℃; for 5h;

DOI:10.1021/jm050257d

Reference yield: 93.0%

3-azidophenylacetic acid (83528-01-2) + H-DTyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 tris-trifluoroacetate → Phaa(3-N3)-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2*2TFA

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; for 1h; Ambient temperature;

DOI:10.1021/jm00038a013

Reference yield: 36.0%

3-azidophenylacetic acid (83528-01-2) → 3-aminocoumaranone (83528-03-4)

Guidance literature:

With trifluorormethanesulfonic acid; In tetrahydrofuran;

DOI:10.1021/jo00145a056

upstream raw materials:

3-amino phenylacetic acid

Downstream raw materials:

3-aminocoumaranone

(+/-)-α-bromo-(3-azidophenyl)acetic acid ethyl ester

(+/-)-α-(3-azidophenyl)-α-[[2-(1H-pyrrol-1-yl)phenyl]oxy]acetic acid ethyl ester

5-(3-azido-phenyl)-5-ethyl-6-oxa-10b-aza-benzo[e]azulen-4-one