4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate

Base Information

Chemical Name:4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate
CAS No.:478836-96-3
Molecular Formula:C₁₁H₁₅NO₅S
Molecular Weight:273.31
Hs Code.:

Synonyms:4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate

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Chemical Property of 4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate

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Technology Process of 4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate

There total 3 articles about 4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 478836-94-1
4-[(2,2-dimethylpropanoyl)amino]-2-methoxy-3-methylphenyl methanesulfonate

: 108-24-7
acetic anhydride

: 478836-96-3
4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate

Guidance literature:: 4-[(2,2-dimethylpropanoyl)amino]-2-methoxy-3-methylphenyl methanesulfonate; With sulfuric acid; In water; butan-1-ol; at 100 ℃; for 14h;

acetic anhydride; With pyridine; In ethyl acetate; at 60 ℃; for 2h;

Reference yield:

: 3251-56-7
2-methoxy-4-nitrophenol

: 478836-96-3
4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.5 h / 20 °C

2.2: 15 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -15 - 0 °C

3.2: 15 h / 0 - 20 °C

4.1: hydrogenchloride / methanol; water / 18 h / 20 °C

4.2: 2.5 h / 60 °C

5.1: sulfuric acid / water; butan-1-ol / 14 h / 100 °C

5.2: 2 h / 60 °C

With hydrogenchloride; n-butyllithium; sulfuric acid; tetrabutylammomium bromide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; butan-1-ol;

Reference yield:

: 98996-81-7
2-methoxy-1-(methoxymethoxy)-4-nitrobenzene

: 478836-96-3
4-(acetylamino)-2-methoxy-3-methylphenyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.5 h / 20 °C

1.2: 15 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -15 - 0 °C

2.2: 15 h / 0 - 20 °C

3.1: hydrogenchloride / methanol; water / 18 h / 20 °C

3.2: 2.5 h / 60 °C

4.1: sulfuric acid / water; butan-1-ol / 14 h / 100 °C

4.2: 2 h / 60 °C

With hydrogenchloride; n-butyllithium; sulfuric acid; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; water; ethyl acetate; butan-1-ol;