N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate

Base Information

Chemical Name:N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate
CAS No.:1190979-87-3
Molecular Formula:C₁₇H₂₆FN₃O₄S
Molecular Weight:387.476
Hs Code.:

Synonyms:N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate

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Chemical Property of N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate

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Technology Process of N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate

There total 1 articles about N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 865450-09-5
(2-Fluoro-4-formyl-phenyl)-carbamic acid tert-butyl ester

: 1190979-87-3
N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate

Guidance literature:: 4-methanesulfonylpiperazine; (2-Fluoro-4-formyl-phenyl)-carbamic acid tert-butyl ester; With acetic acid; In ethanol; at 60 ℃; for 1h;

With sodium cyanoborohydride; In ethanol; at 20 ℃; for 2h;

Reference yield: 88.0%

: 1190979-87-3
N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate

: 1190979-88-4
2-fluoro-4-((4-(methylsulfonyl)-piperazin-1-yl)methyl)aniline

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1190979-87-3
N-tert-butyl 2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylcarbamate

: 1190979-86-2
N-tert-butyl 4-(2-fluoro-4-((4-(methylsulfonyl)piperazin-1-yl)methyl)phenylamino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 20 °C

2.1: acetic acid / ethanol / 1 h / 60 °C

2.2: 2 h / 20 °C

With hydrogenchloride; acetic acid; In 1,4-dioxane; ethanol; dichloromethane;