2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol

Base Information

Chemical Name:2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol
CAS No.:671232-67-0
Molecular Formula:C₂₂H₃₀O₃Si
Molecular Weight:370.564
Hs Code.:

Synonyms:2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol

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Technology Process of 2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol

There total 2 articles about 2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 671232-66-9
tert-Butyl-{(2S,3S)-3-[2-(4-methoxy-benzyloxy)-ethyl]-2-methyl-oxiranylmethoxy}-diphenyl-silane

: 671232-67-0
2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol

Guidance literature:: With disodium hydrogenphosphate; sodium dihydrogenphosphate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chloroform; water; at 20 ℃; for 0.5h; pH=7;
DOI:10.1016/j.tet.2003.09.070

Reference yield:

: 208581-53-7
(E)-ethyl 5-(4-methoxyphenylmethyloxy)-2-methyl-2-pentenoate

: 671232-67-0
2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / LAH / diethyl ether / 0.25 h / 0 °C

2.1: (+)-DET; Ti(O-iPr)4; 4 Angstroem molecular sieves / CH₂Cl₂ / -20 °C

2.2: 95 percent / TBHP / CH₂Cl₂; toluene / -20 °C

3.1: 98 percent / Et₃N; DMAP / CH₂Cl₂ / 4 h / 20 °C

4.1: 88 percent / DDQ; Na₂HPO₄; NaH₂PO₄ / CHCl₃; H₂O / 0.5 h / 20 °C / pH 7

With titanium(IV) isopropylate; dmap; disodium hydrogenphosphate; sodium dihydrogenphosphate; lithium aluminium tetrahydride; diethyl (2R,3R)-tartrate; 4 A molecular sieve; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane; chloroform; water; 2.1: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tet.2003.09.070

Reference yield: 92.0%

: 671232-67-0
2-[(2S,3S)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-oxiranyl]-ethanol

: (E)-(R)-5-(tert-Butyl-diphenyl-silanyloxy)-4-hydroxy-4-methyl-pent-2-enal

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 0 ℃;
DOI:10.1016/j.tet.2003.09.070