dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate

Base Information

Chemical Name:dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate
CAS No.:797034-76-5
Molecular Formula:C₁₆H₂₆NO₆PS
Molecular Weight:391.425
Hs Code.:

Synonyms:dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate

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Chemical Property of dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate

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Technology Process of dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate

There total 3 articles about dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 51220-84-9,68305-83-9
(S)-methyl 4-methyl-2-(4-methylphenylsulfonamido)pentanoate

: 756-79-6
dimethyl methane phosphonate

: 797034-76-5
dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 1.5h;

(S)-methyl 4-methyl-2-(4-methylphenylsulfonamido)pentanoate; In tetrahydrofuran; hexane; at -78 ℃; for 4h;
DOI:10.1016/j.tetasy.2004.08.012

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 797034-76-5
dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -50 °C

2.2: 86 percent / tetrahydrofuran; hexane / 4 h / -78 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tetasy.2004.08.012

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 797034-76-5
dimethyl (S)-3-[(p-toluenesulfonyl)amino]-5-methyl-2-oxohexylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / Et₃N / CH₂Cl₂ / 12 h / 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1.5 h / -50 °C

2.2: 86 percent / tetrahydrofuran; hexane / 4 h / -78 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tetasy.2004.08.012