16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene

Base Information

• Chemical Name: 16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene
• CAS No.: 182161-85-9
• Molecular Formula: C₂₆H₃₁NO₃
• Molecular Weight: 405.537

Synonyms:16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene

Chemical Property of 16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene

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Technology Process of 16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene

There total 1 articles about 16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

benzyllithium (766-04-1) + 3-methoxy-estra-1,3,5(10)-triene-17-keto-16-oxime → 16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene (182161-85-9)

Guidance literature:

In tetrahydrofuran;

DOI:10.1107/S0108270195011309

Reference yield: 84.0%

16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene (182161-85-9) → (4aS,4bR,10bS,12aS)-3-Amino-8-methoxy-12a-methyl-2-phenyl-4a,4b,5,6,10b,11,12,12a-octahydro-4H-chrysen-1-one

Guidance literature:

With potassium hydroxide; In ethylene glycol; at 160 ℃;

DOI:10.1016/S0040-4039(98)02166-2

Reference yield: 78.0%

16-oximino-17α-benzyl-17β-hydroxy-16-hydroxyimino-3-methoxyestra-1,3,5(10)-triene (182161-85-9) → 17β-benzyl-17α-hydroxy-3-methoxyestra-1,3,5(10)-trien-16-one + ((1S,2S,4aS,10aR)-7-Methoxy-2-methyl-2-phenylacetyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthren-1-yl)-acetonitrile

Guidance literature:

With hydrogenchloride; titanium(III) chloride; In ethanol; at 25 ℃;

DOI:10.1016/S0040-4039(97)00996-9

upstream raw materials:

benzyllithium

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