(R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one

Base Information

Chemical Name:(R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one
CAS No.:674483-18-2
Molecular Formula:C₂₉H₃₀FN₃O₂
Molecular Weight:471.575
Hs Code.:

Synonyms:(R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one

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Chemical Property of (R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one

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Technology Process of (R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one

There total 4 articles about (R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 674476-41-6
(R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one

: 79413-93-7
(R)-4-bromo-1,2-butylene epoxide

: 674483-18-2
(R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: (R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-1,3,8-triazaspiro[4.5]decan-4-one; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.5h;

(R)-4-bromo-1,2-butylene epoxide; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 19h;

Reference yield:

: 24171-73-1
1-bromoacenaphthene

: 674483-18-2
(R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

2.1: Resolution of racemate

3.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C

3.2: 19 h / 0 - 20 °C

With sodium hydride; potassium carbonate; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 6306-07-6
1-acenaphthenol

: 674483-18-2
(R)-8-acenaphthen-1-yl-1-(4-fluorophenyl)-3-(2-(R)-oxiranyl-ethyl)-1,3,8-triazaspiro[4.5]decan-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus tribromide / diethyl ether / 0.5 h / 0 - 20 °C

2.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 18 h / 20 °C

3.1: Resolution of racemate

4.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C

4.2: 19 h / 0 - 20 °C

With phosphorus tribromide; sodium hydride; potassium carbonate; In DMF (N,N-dimethyl-formamide); diethyl ether;