(2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

Base Information

Chemical Name:(2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol
CAS No.:1026327-86-5
Molecular Formula:C₁₉H₃₂O₄
Molecular Weight:324.461
Hs Code.:

Synonyms:(2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

Suppliers and Price of (2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

Chemical Property:

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Technology Process of (2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

There total 8 articles about (2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1027486-64-1
(S)-N-[(2R,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-3-hydroxy-2-ethylheptanoyl]-4-isopropyloxazolidine-2-thione

: 1026327-86-5
(2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

Guidance literature:: With sodium tetrahydroborate; water; In tetrahydrofuran; for 1.5h;

Reference yield:

: 82917-27-9
[2S,4R]-2,4-dimethyl-pentanedioic acid monomethyl ester

: 1026327-86-5
(2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

Guidance literature:: Multi-step reaction with 8 steps

1: 97 percent / BH₃*SMe₂ / diethyl ether

2: 96 percent / imidazole, DMAP / CH₂Cl₂ / 1 h / 0 °C

3: 90 percent / LiAlH₄ / diethyl ether / 15 h / 0 °C

4: 91 percent / NaHCO₃, NaCl / dimethylformamide / 1.) r.t., 30 min, 2.) r.t., 16 h

5: 87 percent / TBAF*3H₂O / tetrahydrofuran / 12 h / Ambient temperature

6: 1.) oxalyl chloride, DMSO, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -50 deg C, 2 min, 2.) CH₂Cl₂, -55 to 50 deg C, 20 min

7: 1.) tin(II) triflate, N-ethylpiperidine / 1.) CH₂Cl₂, -45 deg C, 3 h, 2.) CH₂Cl₂, -80 deg C, 20 min

8: 82 percent / NaBH₄, H₂O / tetrahydrofuran / 1.5 h

With 1-ethyl-piperidine; 4-methyl-morpholine; 1H-imidazole; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; tin(II) trifluoromethanesulfonate; oxalyl dichloride; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; dimethyl sulfoxide; sodium chloride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 157733-59-0
[2R,4S]-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester

: 1026327-86-5
(2S,3S,4S,6R)-7-(4-methoxybenzyloxy)-4,6-dimethyl-2-ethylheptane-1,3-diol

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / LiAlH₄ / diethyl ether / 15 h / 0 °C

2: 91 percent / NaHCO₃, NaCl / dimethylformamide / 1.) r.t., 30 min, 2.) r.t., 16 h

3: 87 percent / TBAF*3H₂O / tetrahydrofuran / 12 h / Ambient temperature

4: 1.) oxalyl chloride, DMSO, 2.) N-methylmorpholine / 1.) CH₂Cl₂, -50 deg C, 2 min, 2.) CH₂Cl₂, -55 to 50 deg C, 20 min

5: 1.) tin(II) triflate, N-ethylpiperidine / 1.) CH₂Cl₂, -45 deg C, 3 h, 2.) CH₂Cl₂, -80 deg C, 20 min

6: 82 percent / NaBH₄, H₂O / tetrahydrofuran / 1.5 h

With 1-ethyl-piperidine; 4-methyl-morpholine; sodium tetrahydroborate; lithium aluminium tetrahydride; tin(II) trifluoromethanesulfonate; oxalyl dichloride; tetrabutyl ammonium fluoride; water; sodium hydrogencarbonate; dimethyl sulfoxide; sodium chloride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;