diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate

Base Information

Chemical Name:diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate
CAS No.:528597-19-5
Molecular Formula:C₂₅H₂₉N₅O₆
Molecular Weight:495.535
Hs Code.:

Synonyms:diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate

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Chemical Property of diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate

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Technology Process of diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate

There total 8 articles about diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 528597-17-3
4-[2-(2-amino-4-oxo-3,4-dihydro-pyrido[3,4-d]pyrimidin-6-yl)-ethyl]-benzoic acid

: 528597-19-5
diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate

Guidance literature:: 4-[2-(2-amino-4-oxo-3,4-dihydro-pyrido[3,4-d]pyrimidin-6-yl)-ethyl]-benzoic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-4,3,5-triazine; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

diethyl-L-glutamate hydrochloride; With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1002/jhet.5570390613

Reference yield:

: 174666-19-4
4-(3-oxobutyl)benzoic acid ethyl ester

: 528597-19-5
diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium; ethanol / 20 °C

1.2: 75 percent / glacial acetic acid

2.1: 65 percent / methanol / 0.75 h / Heating

3.1: 60 percent / tert-butyl nitrite; CuCl₂ / acetonitrile / 0.33 h / 65 °C

4.1: triethyl amine; hydrogen / 10 percent palladium on carbon / 2 h / 760 Torr

5.1: 60 percent / ammonia / 80 °C

6.1: 40 percent / dimethylsulfone / 1 h / 160 °C

7.1: aq. sodium hydroxide / 4 h / 20 °C

8.1: N-methylmorpholine; 6-chloro-2,4-dimethoxy-1,2,3-triazine / dimethylformamide / 1 h / 25 °C

8.2: 80 percent / N-methylmorpholine / dimethylformamide / 2 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; tert.-butylnitrite; ethanol; dimethylsulfone; 2-chloro-4,6-dimethoxy-4,3,5-triazine; ammonia; hydrogen; sodium; triethylamine; copper dichloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570390613

Reference yield:

: 528596-98-7
ethyl 4-(5-ethoxycarbonyl-3,5-dioxopentyl)benzoate

: 528597-19-5
diethyl N-[4-[2-(2-amino-4-oxopyrido[3,4-d]pyrimidin-6-yl)ethyl]-benzoyl]-L-glutamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 65 percent / methanol / 0.75 h / Heating

2.1: 60 percent / tert-butyl nitrite; CuCl₂ / acetonitrile / 0.33 h / 65 °C

3.1: triethyl amine; hydrogen / 10 percent palladium on carbon / 2 h / 760 Torr

4.1: 60 percent / ammonia / 80 °C

5.1: 40 percent / dimethylsulfone / 1 h / 160 °C

6.1: aq. sodium hydroxide / 4 h / 20 °C

7.1: N-methylmorpholine; 6-chloro-2,4-dimethoxy-1,2,3-triazine / dimethylformamide / 1 h / 25 °C

7.2: 80 percent / N-methylmorpholine / dimethylformamide / 2 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; tert.-butylnitrite; dimethylsulfone; 2-chloro-4,6-dimethoxy-4,3,5-triazine; ammonia; hydrogen; triethylamine; copper dichloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570390613