3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid

Base Information

Chemical Name:3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid
CAS No.:926295-25-2
Molecular Formula:C₁₈H₁₇ClF₃NO₄
Molecular Weight:403.785
Hs Code.:

Synonyms:3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid

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Chemical Property of 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid

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Technology Process of 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid

There total 6 articles about 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 888740-17-8
ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoate

: 926295-25-2
3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid

Guidance literature:: ethyl 3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoate; With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 50 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 20 ℃;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-80-5
2-benzyloxy-4-isopropoxybenzaldehyde

: 926295-25-2
3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 40 h / 20 °C / 760.05 Torr

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 2 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

4.2: 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil; 1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 888740-15-6
ethyl (2E)-3-(2-benzyloxy-4-isopropoxyphenyl)acrylate

: 926295-25-2
3-(2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-isopropoxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 40 h / 20 °C / 760.05 Torr

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 0 °C

3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

3.2: 20 °C

With palladium 10% on activated carbon; hydrogen; sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.03.036