3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

Base Information

• Chemical Name: 3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>
• CAS No.: 85372-12-9
• Molecular Formula: C₃₀H₃₆Cl₂N₅O₁₀PSi
• Molecular Weight: 756.609

Synonyms:3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

Chemical Property of 3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

Chemical Property:

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Technology Process of 3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate>

There total 12 articles about 3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester (85372-09-4) → 3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> (85372-12-9)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(00)85714-7

Reference yield: 92.0%

3'-O-(tert-butyl)dimethylsilyl-5'-O-(o-monomethoxytrityl)inosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> → 3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> (85372-12-9)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; chloroform; for 0.5h; Ambient temperature;

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 3'-O-(tert-butyl)dimethylsilylinosine-2'-<2,5-dichlorophenyl 2-(p-nitrophenyl)ethyl phosphate> (85372-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) pyridine

2: 92 percent / 2percent p-toluene sulfonic acid / CH₂Cl₂; methanol

With toluene-4-sulfonic acid; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(00)85714-7

upstream raw materials:

Phosphoric acid (2R,3R,4R,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 2,5-dichloro-phenyl ester 2-(4-nitro-phenyl)-ethyl ester

2-(4-nitrophenyl)ethanol

5'-O-(4-methoxytrityl)inosine

9-{(2R,3R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-tetrahydro-furan-2-yl}-1,9-dihydro-purin-6-one

Downstream raw materials:

C₇₄H₈₄Cl₂N₁₀O₂₀P₂Si₂

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