dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate

Base Information

• Chemical Name: dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate
• CAS No.: 108325-77-5
• Molecular Formula: C₂₁H₁₅NO₅
• Molecular Weight: 361.354
• Mol file: 108325-77-5.mol

Synonyms:dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate

Chemical Property of dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate

There total 4 articles about dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-acetonyl-2-benzoylpyridinium bromide (108325-73-1) + 1,4-dimethyl but-2-enedioate (23055-10-9) → dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate (108325-77-5)

Guidance literature:

With chromium(VI) oxide; triethylamine; In N,N-dimethyl-formamide; at 90 ℃; for 5h;

DOI:10.1039/b102449n

Reference yield: 62.0%

dimethyl 3-acetyl-5-benzoylindolizine-1,2-dicarboxylate (108325-74-2) → dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate (108325-77-5)

Guidance literature:

With aluminum oxide; In benzene;

DOI:10.3987/R-1987-01-0199

Reference yield:

phenyl(pyridin-2-yl)methanone (91-02-1) → dimethyl 3-oxo-5-phenyl-3H-pyrrolo<2,1,5-de>quinolizine-1,2-dicarboxylate (108325-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / 3 h / 75 °C

2: 64 percent / K₂CO₃ / tetrahydrofuran / 20 h / Ambient temperature

3: 62 percent / Al₂O₃ / benzene

With aluminum oxide; potassium carbonate; In tetrahydrofuran; benzene;

DOI:10.3987/R-1987-01-0199

upstream raw materials:

dimethyl 3-acetyl-5-benzoylindolizine-1,2-dicarboxylate

N-acetonyl-2-benzoylpyridinium bromide

1,4-dimethyl but-2-enedioate

phenyl(pyridin-2-yl)methanone

Downstream raw materials:

Trifluoro-acetate3-hydroxy-1,2-bis-methoxycarbonyl-5-phenyl-pyrrolo[2,1,5-de]quinolizinylium;