(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

Base Information

Chemical Name:(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester
CAS No.:68314-41-0
Molecular Formula:C₂₉H₂₆N₂O₅
Molecular Weight:482.536
Hs Code.:

(<i>R</i>)-2-((1<i>R</i>)-3-benzyl-7-oxo-(1<i>r</i><i>H</i>,5<i>c</i><i>H</i>)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

Synonyms:(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

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Chemical Property of (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

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Technology Process of (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

There total 12 articles about (R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₆N₂O₅S

: 68314-41-0
(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

Guidance literature:: In ethyl acetate; for 0.5h;

Reference yield:

: C₂₉H₂₆N₂O₅S

: 68314-41-0
(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / 2-methyl-propan-1-ol; dimethyl sulfoxide / 1.5 h / 90 - 100 °C

2: ethyl acetate / 0.5 h

With triphenylphosphine; In 2-methyl-propan-1-ol; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 54639-48-4
(6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

: 68314-41-0
(R)-2-((1R)-3-benzyl-7-oxo-(1rH,5cH)-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-3-hydroxymethyl-but-3-enoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / dichloromethane / 0.5 h / 10 - 15 °C

1.2: 1.5 h / 10 - 15 °C

2.1: sulfuric acid / 1 h / 10 - 15 °C

3.1: sodium tetrahydroborate; acetic acid / dichloromethane; water; methanol / 1 h / -65 - -30 °C

4.1: phosphorus tribromide / N,N-dimethyl-formamide / 4 h / 0 - 25 °C

5.1: toluene-4-sulfonic acid / toluene / 6 h / 85 - 95 °C

6.1: n-butyllithium / 3 h / -60 - -50 °C

7.1: water / 2 h / -60 - -50 °C

8.1: sulfuric acid / water / 5 h / 20 - 25 °C

9.1: cerium(IV) trifluoromethanesulfonate / 2-methyltetrahydrofuran / 0 - 10 °C

9.2: 5 h / 20 - 30 °C

10.1: triphenylphosphine / 2-methyl-propan-1-ol; dimethyl sulfoxide / 1.5 h / 90 - 100 °C

11.1: ethyl acetate / 0.5 h

With sodium tetrahydroborate; n-butyllithium; cerium(IV) trifluoromethanesulfonate; sulfuric acid; phosphorus tribromide; toluene-4-sulfonic acid; acetic acid; triethylamine; triphenylphosphine; In 2-methyltetrahydrofuran; methanol; dichloromethane; 2-methyl-propan-1-ol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene;