N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine

Base Information

Chemical Name:N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine
CAS No.:1449388-29-7
Molecular Formula:C₂₁H₂₀BrNO₄
Molecular Weight:430.298
Hs Code.:

Synonyms:N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine

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Technology Process of N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine

There total 2 articles about N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 53207-00-4
1-bromo-2-(bromomethyl)-4,5-dimethoxybenzene

: 219781-97-2
N-methyl-6,7-(methylenedioxy)-1-naphthylamine

: 1449388-29-7
N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 10h; Inert atmosphere; Sealed tube;
DOI:10.1021/jo400890k

Reference yield:

: 53811-49-7
naphtho[2,3-d][1,3]dioxol-5-amine

: 1449388-29-7
N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / toluene / 4 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 6.42 h / 0 - 80 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere; Sealed tube

With lithium aluminium tetrahydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo400890k

Reference yield: 65.0%

: 1449388-29-7
N-(2-bromo-4,5-dimethoxybenzyl)-N-methylnaphtho[2,3-d][1,3]dioxol-5-amine

: 13063-06-4
dihydronitidine

Guidance literature:: With 1,10-Phenanthroline; potassium tert-butylate; In 1,3,5-trimethyl-benzene; at 100 - 110 ℃; for 24h; Reagent/catalyst; Time; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1021/jo400890k