2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide

Base Information

Chemical Name:2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide
CAS No.:1586787-79-2
Molecular Formula:C₂₈H₄₃N₃O₂
Molecular Weight:453.668
Hs Code.:

Synonyms:2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide

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Chemical Property of 2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide

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Technology Process of 2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide

There total 8 articles about 2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1586791-20-9
2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carbonyl chloride

: 131288-67-0
(2S)-2-amino-3-cyclohexyl-1-propanol

: 1586787-79-2
2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -10 - 20 ℃;

Reference yield:

: methyl 4-(1-ethyl-propylamino)-3-nitro-benzoate

: 1586787-79-2
2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 3750.38 Torr

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

3.1: hydrogenchloride / 0.5 h / 140 °C / Microwave irradiation

4.1: sodium hydroxide; water / methanol / 1 h / 140 °C / Microwave irradiation

4.2: pH 5

5.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 20 °C

With hydrogenchloride; oxalyl dichloride; palladium 10% on activated carbon; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1586787-79-2
2-cyclopentylmethyl-1-(1-ethyl-propyl)-1H-benzoimidazole-5-carboxylic acid ((S)-1-cyclohexylmethyl-2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 3 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 3750.38 Torr

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5.1: hydrogenchloride / 0.5 h / 140 °C / Microwave irradiation

6.1: sodium hydroxide; water / methanol / 1 h / 140 °C / Microwave irradiation

6.2: pH 5

7.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -10 - 20 °C

With hydrogenchloride; oxalyl dichloride; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;