(S)-1-naphthyl(phenyl)phosphinylacetic acid

Base Information

Chemical Name:(S)-1-naphthyl(phenyl)phosphinylacetic acid
CAS No.:871246-58-1
Molecular Formula:C₁₈H₁₅O₂P
Molecular Weight:294.29
Hs Code.:

Synonyms:(S)-1-naphthyl(phenyl)phosphinylacetic acid

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Chemical Property of (S)-1-naphthyl(phenyl)phosphinylacetic acid

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Technology Process of (S)-1-naphthyl(phenyl)phosphinylacetic acid

There total 7 articles about (S)-1-naphthyl(phenyl)phosphinylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (S)-1-naphthyl(phenyl)phosphinylacetic acid borane

: 871246-58-1
(S)-1-naphthyl(phenyl)phosphinylacetic acid

Guidance literature:: (S)-1-naphthyl(phenyl)phosphinylacetic acid borane; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

With sodium hydroxide;
DOI:10.1016/j.tetlet.2005.09.136

Reference yield:

: C₁₇H₁₅OP*BH₃

: 871246-58-1
(S)-1-naphthyl(phenyl)phosphinylacetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂SO₄ / methanol

1.2: H₂O

2.1: s-BuLi / cyclohexane; tetrahydrofuran / 2 h / -78 °C

2.2: cyclohexane; tetrahydrofuran / 3 h / -40 °C

3.1: TFA / CH₂Cl₂ / 2 h / 0 °C

3.2: 90 percent / aq. NaOH

With sulfuric acid; sec.-butyllithium; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; cyclohexane;
DOI:10.1016/j.tetlet.2005.09.136

Reference yield:

: (S)-Methyl-naphthalen-1-yl-phenyl-phosphane; compound with borane

: 871246-58-1
(S)-1-naphthyl(phenyl)phosphinylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: s-BuLi / cyclohexane; tetrahydrofuran / 2 h / -78 °C

1.2: cyclohexane; tetrahydrofuran / 3 h / -40 °C

2.1: TFA / CH₂Cl₂ / 2 h / 0 °C

2.2: 90 percent / aq. NaOH

With sec.-butyllithium; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1016/j.tetlet.2005.09.136