N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

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Chemical Name:N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide
CAS No.:1383622-69-2
Molecular Formula:C₂₆H₂₅F₃N₆O₂
Molecular Weight:510.519
Hs Code.:

Synonyms:N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

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Chemical Property of N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

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Technology Process of N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

There total 8 articles about N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383622-63-6
N-(5-(6-(4-cyano-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

: 1383622-69-2
N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Guidance literature:: With hydroxylamine hydrochloride; triethylamine; In ethanol; at 80 ℃; for 2h;

Reference yield:

: 5337-93-9
4'-methylpropiophenone

: 1383622-69-2
N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid / 0 - 10 °C

2.1: bromine / dichloromethane / 20 °C

3.1: acetonitrile / 16 h / 80 °C

4.1: acetic acid; iron / ethanol; water / 6 h / 80 °C

5.1: pyridine / acetonitrile / 4 h / 20 °C

6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C

6.2: 1 h

6.3: pH 5

7.1: potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / isopropyl alcohol; water / 5 h / 90 °C / Inert atmosphere

8.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 80 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; hydroxylamine hydrochloride; bromine; nitric acid; potassium acetate; iron; potassium carbonate; acetic acid; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In 1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 50630-41-6
1-(4'-methyl-3'-nitrophenyl)-propane-1-one

: 1383622-69-2
N-(5-(6-(4-(N'-hydroxycarbamimidoyl)-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine / dichloromethane / 20 °C

2.1: acetonitrile / 16 h / 80 °C

3.1: acetic acid; iron / ethanol; water / 6 h / 80 °C

4.1: pyridine / acetonitrile / 4 h / 20 °C

5.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 16 h / 90 °C

5.2: 1 h

5.3: pH 5

6.1: potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / palladium diacetate / isopropyl alcohol; water / 5 h / 90 °C / Inert atmosphere

7.1: hydroxylamine hydrochloride; triethylamine / ethanol / 2 h / 80 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; hydroxylamine hydrochloride; bromine; potassium acetate; iron; potassium carbonate; acetic acid; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In 1,4-dioxane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;