1H-Pyrrole-2-carboxylicacid,5-[(hydroxyimino)methyl]-,methylester(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxylicacid,5-[(hydroxyimino)methyl]-,methylester(9CI)
• CAS No.: 263382-26-9
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Mol file: 263382-26-9.mol

Synonyms:1H-Pyrrole-2-carboxylicacid,5-[(hydroxyimino)methyl]-,methylester(9CI)

Chemical Property of 1H-Pyrrole-2-carboxylicacid,5-[(hydroxyimino)methyl]-,methylester(9CI)

Chemical Property:

• PSA: 74.68000
• LogP: 0.60940

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxylicacid,5-[(hydroxyimino)methyl]-,methylester(9CI)

There total 4 articles about 1H-Pyrrole-2-carboxylicacid,5-[(hydroxyimino)methyl]-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl 5-formyl-1H-pyrrole-2-carboxylate (1197-13-3) → Methyl 5-[(hydroxyimino)methyl]-1H-pyrrole-2-carboxylate (263382-26-9)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; at 65 ℃;

DOI:10.1002/(SICI)1521-3765(20000218)6:4<709::AID-CHEM709>3.0.CO;2-6

Reference yield:

methyl Pyrrole-2-carboxylate (1193-62-0) → Methyl 5-[(hydroxyimino)methyl]-1H-pyrrole-2-carboxylate (263382-26-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / POCl₃

2: 58 percent / aq. NH₂OH*HCl; K₂CO₃ / 65 °C

With hydroxylamine hydrochloride; potassium carbonate; trichlorophosphate; 1: Formylation / 2: Condensation;

DOI:10.1002/(SICI)1521-3765(20000218)6:4<709::AID-CHEM709>3.0.CO;2-6

Reference yield:

pyrrol-2-yl trichloromethyl ketone (35302-72-8) → Methyl 5-[(hydroxyimino)methyl]-1H-pyrrole-2-carboxylate (263382-26-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / NaOMe

2: 63 percent / POCl₃

3: 58 percent / aq. NH₂OH*HCl; K₂CO₃ / 65 °C

With hydroxylamine hydrochloride; sodium methylate; potassium carbonate; trichlorophosphate; 1: Substitution / 2: Formylation / 3: Condensation;

DOI:10.1002/(SICI)1521-3765(20000218)6:4<709::AID-CHEM709>3.0.CO;2-6

upstream raw materials:

methyl 5-formyl-1H-pyrrole-2-carboxylate

methyl Pyrrole-2-carboxylate

pyrrol-2-yl trichloromethyl ketone

Downstream raw materials:

Methyl 5-(aminomethyl)-1H-pyrrole-2-carboxylate