Technology Process of N-<4-carbonyl>pyridin-2-ylmethyl)>aminobenzoyl>-L-glutamate
There total 8 articles about N-<4-carbonyl>pyridin-2-ylmethyl)>aminobenzoyl>-L-glutamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
3 A molecular sieve; sodium cyanoborohydride; trifluoroacetic acid;
In
dichloromethane;
for 120h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 51 percent / DIBAL-H / CH2Cl2 / 3 h / -78 °C
2: 98 percent / pyridinium toluene-p-sulphonate / methanol
3: 1.) KH / 1.) THF, 4 h, 2.) THF, 1.5 h
4: 78 percent / 15 percent aq. H2SO4 / CH2Cl2 / 6 h / Ambient temperature
5: 57 percent / NaBH3CN, TFA, molecular sieves 3A / CH2Cl2 / 120 h
With
3 A molecular sieve; sulfuric acid; pyridinium p-toluenesulfonate; potassium hydride; diisobutylaluminium hydride; sodium cyanoborohydride; trifluoroacetic acid;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / pyridinium toluene-p-sulphonate / methanol
2: 1.) KH / 1.) THF, 4 h, 2.) THF, 1.5 h
3: 78 percent / 15 percent aq. H2SO4 / CH2Cl2 / 6 h / Ambient temperature
4: 57 percent / NaBH3CN, TFA, molecular sieves 3A / CH2Cl2 / 120 h
With
3 A molecular sieve; sulfuric acid; pyridinium p-toluenesulfonate; potassium hydride; sodium cyanoborohydride; trifluoroacetic acid;
In
methanol; dichloromethane;
