tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate
CAS No.:1218761-73-9
Molecular Formula:C₂₇H₂₈F₇N₃O₄
Molecular Weight:591.526
Hs Code.:

tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

Synonyms:tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

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Chemical Property of tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

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Technology Process of tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

There total 2 articles about tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 205596-29-8
4-nitrophenyl (tetrahydro-2H-pyran-4-yl)carbonate

: 1218761-04-6
1-[3,5-bis(trifluoromethyl)phenyl]-3-[(3S,4R)-4-(4-fluorophenyl)pyrrolidin-3-yl]-1,3-dimethylurea monohydrochloride

: 1218761-73-9
tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 10 - 60 ℃; for 106h;

Reference yield:

: 1218761-03-5
tert-butyl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

: 1218761-73-9
tetrahydro-2H-pyran-4-yl (3S,4R)-3-[{[3,5-bis(trifluoromethyl)phenyl](methyl)carbamoyl}(methyl)amino]-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / isopropyl alcohol / 2.5 h / 10 - 45 °C

2: potassium carbonate / N,N-dimethyl-formamide / 106 h / 10 - 60 °C

With hydrogenchloride; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;