2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide

Base Information

• Chemical Name: 2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide
• CAS No.: 1023591-44-7
• Molecular Formula: C₁₄H₁₅BrN₄OS
• Molecular Weight: 367.269
• Mol file: 1023591-44-7.mol

Synonyms:2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide

Chemical Property of 2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide

There total 1 articles about 2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(2-(2-bromothiazole-4-carboxamido)phenyl)piperazine-1-carboxylate (1023298-53-4) → 2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide (1023591-44-7)

Guidance literature:

With trifluoroacetic acid; for 0.166667h;

Reference yield: 98.0%

2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide (1023591-44-7) + 4-tert-butylimidazole-2-thiol (14395-90-5) → C21H26N6OS2

Guidance literature:

With 1-ethyl-2,2,4,4,4-pentakis(dimethylamino)-2λ⁵,4λ⁵-catenadi(phosphazene); In N,N-dimethyl-formamide; Reagent/catalyst; Solvent;

DOI:10.1038/s41586-018-0056-8

Reference yield: 98.0%

2-bromo-thiazole-4-carboxylic acid (2-piperazin-1-yl-phenyl)-amide (1023591-44-7) + 3-Aminophenylboronic acid (30418-59-8,280563-63-5) → C20H21N5OS

Guidance literature:

With potassium phosphate; methanesulfonato(2-dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl)(2’-methylamino-1,1‘-biphenyl-2-yl)palladium(II); In 1-methyl-pyrrolidin-2-one; water; Reagent/catalyst; Solvent;

DOI:10.1038/s41586-018-0056-8

upstream raw materials:

tert-butyl 4-(2-(2-bromothiazole-4-carboxamido)phenyl)piperazine-1-carboxylate

Downstream raw materials:

C₂₂H₂₅N₅OS

C₂₁H₂₃N₅OS

C₂₁H₂₂N₆OS

C₂₀H₂₂N₆OS₂