benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate

Base Information

• Chemical Name: benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate
• CAS No.: 210359-37-8
• Molecular Formula: C₃₂H₃₄N₂O₄
• Molecular Weight: 510.633
• Mol file: 210359-37-8.mol

Synonyms:benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate

Chemical Property of benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate

There total 5 articles about benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3,4-dimethyl-pyrrole-2-carboxylic acid benzyl ester (954-92-7) + benzyl 8-acetoxy-3-methylcyclohepta[b]pyrrole-2-carboxylate (167401-15-2) → benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate (210359-37-8)

Guidance literature:

With toluene-4-sulfonic acid; In acetic acid; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(98)00327-5

Reference yield:

(toluene-4-sulfonylamino)acetic acid benzyl ester (63366-76-7) → benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate (210359-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.53 g

2: 78 percent / p-toluenesulfonic acid / acetic acid / 2 h / 20 °C

With toluene-4-sulfonic acid; In acetic acid; 2: Condensation;

DOI:10.1016/S0040-4020(98)00327-5

Reference yield:

benzyl 2,3-dioxobutanoate-2-phenylhydrazone → benzyl 8-(5-benzyloxycarbonyl-3,4-dimethyl-2-pyrrolyl)-3-methylcyclohepta[b]pyrrole-2-carboxylate (210359-37-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / sodium acetate; zinc / acetic acid / 130 °C

2: 53 percent / CH₂Cl₂ / 3 h / 20 °C

3: 78 percent / p-toluenesulfonic acid / acetic acid / 2 h / 20 °C

With sodium acetate; toluene-4-sulfonic acid; zinc; In dichloromethane; acetic acid; 1: Cyclization / 2: Acetoxylation / 3: Condensation;

DOI:10.1016/S0040-4020(98)00327-5

upstream raw materials:

3,4-dimethyl-pyrrole-2-carboxylic acid benzyl ester

benzyl 8-acetoxy-3-methylcyclohepta[b]pyrrole-2-carboxylate

(toluene-4-sulfonylamino)acetic acid benzyl ester

benzyl 3-methylcyclohepta[b]pyrrole-2-carboxylate