4-Chloro-2,6-dimethylpyridine

Base Information

• Chemical Name: 4-Chloro-2,6-dimethylpyridine
• CAS No.: 3512-75-2
• Molecular Formula: C7H8ClN
• Molecular Weight: 141.6
• Hs Code.: 2933399090
• Mol file: 3512-75-2.mol

Synonyms:2,6-Lutidine,4-chloro- (6CI,7CI,8CI);2,6-Dimethyl-4-chloropyridine;

Chemical Property of 4-Chloro-2,6-dimethylpyridine

Chemical Property:

• Vapor Pressure: 1.251mmHg at 25°C
• Refractive Index: 1.524
• Boiling Point: 179.823 °C at 760 mmHg
• PKA: 5.22±0.10(Predicted)
• Flash Point: 78.047 °C
• PSA: 12.89000
• Density: 1.114 g/cm³
• LogP: 2.35180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-2,6-dimethylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2,6-dimethylpyridine

There total 16 articles about 4-Chloro-2,6-dimethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Hydroxy-2,6-dimethyl-pyridin-N-oxid (42051-83-2) → 4-chloro-2,6-lutidine (3512-75-2)

Guidance literature:

With phosphorus trichloride; In chloroform;

DOI:10.1016/j.bmcl.2003.11.049

Reference yield: 91.0%

2,6-dimethylpyridin-4-ol (13603-44-6) → 4-chloro-2,6-lutidine (3512-75-2)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 2h;

DOI:10.1039/c9dt04714j

Reference yield: 72.0%

2,6-lutidine N-oxide (1073-23-0) → 4-chloro-2,6-lutidine (3512-75-2)

Guidance literature:

2,6-lutidine N-oxide; With hydrogenchloride; In water; at 23 ℃; for 15h; Cooling with ice;

With trichlorophosphate; for 15h; Reflux;

With ethanol; triethylamine; for 15h; Reflux;

DOI:10.1021/jacs.6b06144

upstream raw materials:

4-amino-2,6-lutidine

2,6-dimethyl-1H-pyridin-4-one

2,6-dimethylpyridine N-oxide hydrochloride

triethylamine

Downstream raw materials:

2,6-dimethyl-4-p-tolyloxy-pyridine

4-methoxy-2,6-dimethylpyridine

(2,6-dimethyl-[4]pyridyl)-phenyl-acetonitrile

4-benzyloxy-2,6-dimethyl-pyridine

Refernces

• 1、 Yepremyan, Akop,Mekhail, Magy A.,Niebuhr, Brian P.,Pota, Kristof,Sadagopan, Nishanth,Schwartz, Timothy M.,Green, Kayla N.. "Synthesis of 12-Membered Tetra-aza Macrocyclic Pyridinophanes Bearing Electron-Withdrawing Groups". . p. 4988 - 4998. Retrieved 2020/04/02.
• 2、 -. "PYRAZOLOQUINOLINE DERIVATIVES". Paragraph 0485; 0486. . Retrieved 2013/06/26.