3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

Base Information

Chemical Name:3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester
CAS No.:868071-16-3
Molecular Formula:C₁₁H₁₁F₃O₃
Molecular Weight:248.202
Hs Code.:

Synonyms:3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

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Chemical Property of 3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

Chemical Property:

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Technology Process of 3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

There total 4 articles about 3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

: 769195-26-8
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

: 868071-16-3
3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

Guidance literature:: With formic acid; In methanol; at 65 ℃; for 2h; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield:

: 769195-26-8
4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester

: 1138326-05-2
(R)-methyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate

: 868071-16-3
3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

Guidance literature:: With (p-cymene)ruthenium(II) chloride; triethylamine; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; In dichloromethane; at 35 ℃; for 1h;

4-(2,4,5-trifluoro-phenyl)-3-oxo-butyric acid methyl ester; With tetra-(n-butyl)ammonium iodide; In water; sodium formate; at 40 ℃; for 0.9h; optical yield given as %ee; Ultrasonic irradiation;
DOI:10.1016/j.catcom.2009.12.002

Reference yield:

: 764667-64-3
5-(1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 868071-16-3
3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybenzenebutanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / Reflux

2: hydrogen / (S)-BINAP RuCl₂-triethylamine / methanol / 80 - 85 °C / 4413.43 - 4781.22 Torr

With hydrogen; (S)-BINAP RuCl₂-triethylamine; In methanol;