Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methyl-2-propenyl]-, 1,1-

Base Information

• Chemical Name: Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methyl-2-propenyl]-, 1,1-
• CAS No.: 263016-98-4
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.266
• Mol file: 263016-98-4.mol

Synonyms:Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methyl-2-propenyl]-, 1,1-

Chemical Property of Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methyl-2-propenyl]-, 1,1-

Chemical Property:

• PSA: 58.56000
• LogP: 1.83900

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methyl-2-propenyl]-, 1,1-

There total 2 articles about Carbamic acid, [(1S)-1-(hydroxymethyl)-1-methyl-2-propenyl]-, 1,1- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-Amino-2-methyl-but-3-en-1-ol; hydrochloride → (S)-2-((tert-butoxycarbonyl)amino)-2-methyl-3-buten-1-ol (263016-98-4)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0957-4166(99)00533-9

Reference yield:

(S)-N-(tert-butoxycarbonyl)-4-vinyl-2,2,4-trimethyl-3-oxazolidine (252953-44-9) → (S)-2-((tert-butoxycarbonyl)amino)-2-methyl-3-buten-1-ol (263016-98-4)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. aq. HCl / 20 °C

2: 88 percent / aq. Na₂CO₃ / tetrahydrofuran / 20 °C

With hydrogenchloride; sodium carbonate; In tetrahydrofuran; 1: cleavage / 2: Acylation;

DOI:10.1016/S0957-4166(99)00533-9

upstream raw materials:

di-tert-butyl dicarbonate

(S)-N-(tert-butoxycarbonyl)-4-vinyl-2,2,4-trimethyl-3-oxazolidine