(4R)-5-amino-4-(1,3-dioxoisoindol-2-yl)-5-oxopentanoic acid

Base Information

• Chemical Name: (4R)-5-amino-4-(1,3-dioxoisoindol-2-yl)-5-oxopentanoic acid
• CAS No.: 2614-09-7
• Molecular Formula: C₁₃H₁₂N₂O₅
• Molecular Weight: 276.249
• NSC Number: 92155
• Nikkaji Number: J3.498.187F
• Mol file: 2614-09-7.mol

Synonyms:2614-09-7;(4R)-5-amino-4-(1,3-dioxoisoindol-2-yl)-5-oxopentanoic acid;NSC92155;NSC-92155

Chemical Property of (4R)-5-amino-4-(1,3-dioxoisoindol-2-yl)-5-oxopentanoic acid

Chemical Property:

• Vapor Pressure: 1.8E-14mmHg at 25°C
• Boiling Point: 583.8°Cat760mmHg
• Flash Point: 306.9°C
• PSA: 117.77000
• Density: 1.508g/cm³
• LogP: 0.63950
• Solubility.: Dimethylformamide, Dimethyl Sulfoxide,
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 276.07462149
• Heavy Atom Count: 20
• Complexity: 438

Purity/Quality:

99%min ^*data from raw suppliers

D-4-Phthalimido-glutaramicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)C(CCC(=O)O)C(=O)N
• Isomeric SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)[C@H](CCC(=O)O)C(=O)N
• Uses: Thalidomide (T338850) derivative.

Technology Process of (4R)-5-amino-4-(1,3-dioxoisoindol-2-yl)-5-oxopentanoic acid

There total 2 articles about (4R)-5-amino-4-(1,3-dioxoisoindol-2-yl)-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-thalidomide (2614-06-4) → (R)-4-phthalimidoglutaramic acid (2614-09-7,2820-40-8) + (S)-thalidomide (841-67-8) + (R)-2-phthalimidoglutaramic acid (2110-19-2,174591-46-9) + α-(o-carboxybenzamido)-D-glutarimide (131-68-0,29883-18-9)

Guidance literature:

human serum albumin; In phosphate buffer; at 37 ℃; pH=7.40; Further Variations:; Catalysts; pH-values; catalyst, buffer concentration; Kinetics;

DOI:10.1021/tx9801817

Reference yield:

→ (R)-4-phthalimidoglutaramic acid (2614-09-7,2820-40-8)

Guidance literature:

D-Isoglutamin, N-Ethoxycarbonyl-phthalimid;

upstream raw materials:

(R)-thalidomide

Refernces