Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate
CAS No.:263016-08-6
Molecular Formula:C12H10 Cl N O3 S
Molecular Weight:283.735
Hs Code.:2934100090
DSSTox Substance ID:DTXSID001331593
Wikidata:Q27208955
ChEMBL ID:CHEMBL1377190
Mol file:263016-08-6.mol

Synonyms:263016-08-6;ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate;ethyl 2-(4-chlorophenyl)-4-hydroxythiazole-5-carboxylate;Maybridge1_008572;MLS000850997;CHEMBL1377190;SCHEMBL15048955;HMS565N14;CHEBI:120812;DTXSID001331593;HMS2800M14;MFCD00816787;AKOS025393828;CCG-256270;BP-10129;SMR000457014;TS-01012;CS-0206103;FT-0625866;E10099;A818368;Q27208955;Ethyl2-(4-chlorophenyl)-4-hydroxythiazole-5-carboxylate;2-(4-chlorophenyl)-5-[ethoxy(hydroxy)methylene]thiazol-4-one;2-(4-chlorophenyl)-4-hydroxy-thiazole-5-carboxylic acid ethyl ester;2-(4-chlorophenyl)-5-[ethoxy(hydroxy)methylidene]-4-thiazolone;5-Thiazolecarboxylic acid, 2-(4-chlorophenyl)-4-hydroxy-, ethyl ester;ethyl 2-(4-chlorophenyl)-4-hydroxythiazole-5-carboxylate, AldrichCPR

Suppliers and Price of Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate
1 g
$ 64.00

Matrix Scientific
Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate 97%
10g
$ 788.00

Matrix Scientific
Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate 97%
1g
$ 95.00

Crysdot
Ethyl2-(4-chlorophenyl)-4-hydroxythiazole-5-carboxylate 97%
10g
$ 488.00

CHESS?
MC002968:2-(4-Chloro-phenyl)-4-hydroxy-thiazole-5-carboxylicacidethylester 95
1 g
$ 336.00

Atlantic Research Chemicals
Ethyl2-(4-Chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate 95%
10gm:
$ 353.46

American Custom Chemicals Corporation
ETHYL 2-(4-CHLOROPHENYL)-4-HYDROXY-1,3-THIAZOLE-5-CARBOXYLATE 95.00%
1G
$ 635.71

AHH
Ethyl2-(4-chlorophenyl)-4-hydroxythiazole-5-carboxylate 97%
50g
$ 418.00

Advanced Chemicals Intermediatesced Chemicals Intermediates
2-(4-Chloro-phenyl)-4-hydroxy-thiazole-5-carboxylicacidethylester 95%+
5g
$ 195.75

Acints
2-(4-Chloro-phenyl)-4-hydroxy-thiazole-5-carboxylicacidethylester 95%+
10g
$ 362.50

Total 9 raw suppliers

Chemical Property of Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate

Chemical Property:

Vapor Pressure:2.07E-07mmHg at 25°C
Melting Point:137-139
Refractive Index:1.614
Boiling Point:413°Cat760mmHg
Flash Point:203.6°C
PSA：87.66000
Density:1.403g/cm³
LogP:3.34580
XLogP3:4.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:283.0069920
Heavy Atom Count:18
Complexity:297

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(N=C(S1)C2=CC=C(C=C2)Cl)O

Technology Process of Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate

There total 2 articles about Ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 685-87-0
Diethyl 2-bromomalonate

: 2521-24-6
4-chlorothiobenzamide

: 263016-08-6
ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate

Guidance literature:: In ethanol; at 100 ℃; for 0.5h; Microwave irradiation;
DOI:10.1021/acs.jmedchem.1c01647

Reference yield: 71.0%

: 263016-08-6
ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate

Guidance literature:: In 1,4-dioxane; at 80 ℃;

Reference yield: 96.0%

: 263016-08-6
ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate

: 107-30-2
chloromethyl methyl ether

: 1445752-90-8
ethyl 2-(4-chlorophenyl)-4-(methoxymethoxy)-1,3-thiazole-5-carboxylate

Guidance literature:: ethyl 2-(4-chlorophenyl)-4-hydroxy-1,3-thiazole-5-carboxylate; chloromethyl methyl ether; With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.25h;

In N,N-dimethyl-formamide; at 60 ℃;