(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

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Chemical Name:(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one
CAS No.:188396-12-5
Molecular Formula:C₂₄H₄₇NO₄Si₂
Molecular Weight:469.812
Hs Code.:

Synonyms:(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

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Chemical Property of (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

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Technology Process of (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

There total 4 articles about (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 188396-11-4
1-{(2S,3S)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-methoxy-2-oxo-cyclohexanecarboxylic acid allyl ester

: 188396-12-5
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

: 181798-21-0
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-((1R,3S)-3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

Guidance literature:: With formic acid; palladium diacetate; triphenylphosphine; In ethyl acetate; for 2.5h; Heating;
DOI:10.1021/ja962006n

Reference yield:

: 7429-44-9
2-methoxycyclohexanone

: 188396-12-5
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH, KH / 1.) THF, reflux, 2.) THF, reflux, 12 h

2: 1.) NaH / 1.) THF, -20 deg C, 45 min, 2.) THF, -20 deg C, 2 h

3: 2,6-lutidine / CH₂Cl₂ / 0.5 h

4: 43 percent / palladium acetate, triphenylphosphine, formic acid / ethyl acetate / 2.5 h / Heating

With 2,6-dimethylpyridine; formic acid; palladium diacetate; potassium hydride; sodium hydride; triphenylphosphine; In dichloromethane; ethyl acetate;
DOI:10.1021/ja962006n

Reference yield:

: 188396-09-0
3-Methoxy-2-oxo-cyclohexanecarboxylic acid allyl ester

: 188396-12-5
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-(3-methoxy-2-oxo-cyclohexyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, -20 deg C, 45 min, 2.) THF, -20 deg C, 2 h

2: 2,6-lutidine / CH₂Cl₂ / 0.5 h

3: 43 percent / palladium acetate, triphenylphosphine, formic acid / ethyl acetate / 2.5 h / Heating

With 2,6-dimethylpyridine; formic acid; palladium diacetate; sodium hydride; triphenylphosphine; In dichloromethane; ethyl acetate;
DOI:10.1021/ja962006n