1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

Base Information

Chemical Name:1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea
CAS No.:1307949-53-6
Molecular Formula:C₂₀H₂₁F₄N₃O
Molecular Weight:395.4
Hs Code.:

Synonyms:1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

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Chemical Property of 1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

Chemical Property:

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Technology Process of 1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

There total 3 articles about 1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307683-84-6
1-benzyl-N-ethylazetidin-3-amine

: 1-fluoro-4-isocyanato-2-(trifluoromethyl)benzene

: 1307949-53-6
1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 19h; Inert atmosphere;

Reference yield:

: 1307683-81-3
1-benzylazetidin-3-amine dihydrochloride

: 1307949-53-6
1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

: 1000577-78-5
tert-butyl 1-benzylazetidin-3-ylcarbamate

: 1307949-53-6
1-(1-benzylazetidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 18 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

2.2: 16 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 19 h / 20 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;