2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid

Base Information

Chemical Name:2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid
CAS No.:253442-23-8
Molecular Formula:C₂₂H₁₉N₃O₃S₂
Molecular Weight:437.543
Hs Code.:

Synonyms:2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid

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Chemical Property of 2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid

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Technology Process of 2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid

There total 10 articles about 2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 427895-09-8
tert-butyl-2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-yl-phenylthio) propionate

: 253442-23-8
2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/S0968-0896(01)00311-X

Reference yield:

: 7338-27-4
4-methoxy-2-methylene-4-oxobutanoic acid

: 253442-23-8
2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 67.5 percent / H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

2: 75.3 percent / LiOH / H₂O; dioxane / 2.5 h / 0 - 20 °C

3: 80.2 percent / NaOMe / methanol / 20 °C

4: N-methylmorpholine / 1,2-dimethoxy-ethane / 20 °C

5: 34 g / NaBH₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / -10 °C

6: 88 percent / Ph₃P; DIAD / tetrahydrofuran / 1.5 h / 0 - 20 °C

7: 71 percent / LiCl / Pd(PPh₃)4 / toluene / Heating

8: 93 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; sulfuric acid; sodium methylate; triphenylphosphine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 6: Mitsunobu reaction / 7: Stille reaction;
DOI:10.1016/S0968-0896(01)00311-X

Reference yield:

: 97-65-4,25119-64-6
2-methylenesuccinic acid

: 253442-23-8
2-[2-(4-oxo-4-benzo[d][1,2,3]triazin-3-ylethyl)]-3-(4-thien-3-ylphenylthio) propionic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / Amberlyst 15 H⁺ resin / 72 h / 20 °C

2: 67.5 percent / H₂SO₄ / CH₂Cl₂ / 0 - 20 °C

3: 75.3 percent / LiOH / H₂O; dioxane / 2.5 h / 0 - 20 °C

4: 80.2 percent / NaOMe / methanol / 20 °C

5: N-methylmorpholine / 1,2-dimethoxy-ethane / 20 °C

6: 34 g / NaBH₄ / 1,2-dimethoxy-ethane; H₂O / 1 h / -10 °C

7: 88 percent / Ph₃P; DIAD / tetrahydrofuran / 1.5 h / 0 - 20 °C

8: 71 percent / LiCl / Pd(PPh₃)4 / toluene / Heating

9: 93 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; Amberlyst 15 H⁺ resin; sulfuric acid; sodium methylate; triphenylphosphine; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; 7: Mitsunobu reaction / 8: Stille reaction;
DOI:10.1016/S0968-0896(01)00311-X