4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

Base Information

Chemical Name:4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl
CAS No.:1142223-35-5
Molecular Formula:C₂₁H₂₂BrFO
Molecular Weight:389.307
Hs Code.:

Synonyms:4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

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Chemical Property of 4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

Chemical Property:

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Technology Process of 4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

There total 8 articles about 4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1142223-31-1
(2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol

: 1142223-35-5
4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

Guidance literature:: With pyridine; bromine; triphenylphosphine; In tetrachloromethane; dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1011531-89-7
2-(5,5-dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1 ,3 ,2-dioxaborolane

: 1142223-35-5
4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0 - 40 °C

2.2: 0 °C

2.3: 0 °C

3.1: pyridine; bromine; triphenylphosphine / tetrachloromethane; dichloromethane / 0 - 20 °C

With pyridine; potassium phosphate; lithium aluminium tetrahydride; bromine; triphenylphosphine; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 939050-79-0
ethyl 3-chloro-4-{[(trifluoromethyl)sulfonyl]oxy}benzoate

: 1142223-35-5
4-(bromomethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 100 °C / Inert atmosphere

2.1: potassium phosphate / 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate / water; N,N-dimethyl-formamide / 100 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0 - 40 °C

3.2: 0 °C

3.3: 0 °C

4.1: pyridine; bromine; triphenylphosphine / tetrachloromethane; dichloromethane / 0 - 20 °C

With pyridine; potassium phosphate; lithium aluminium tetrahydride; bromine; potassium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; palladium diacetate; In tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;