ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate

Base Information

Chemical Name:ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate
CAS No.:937055-44-2
Molecular Formula:C₂₉H₃₁ClN₄O₆
Molecular Weight:567.041
Hs Code.:

Synonyms:ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate

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Chemical Property of ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate

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Technology Process of ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate

There total 11 articles about ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 937057-90-4
(4R,6S)-4-(2-azidoethyl)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepine

: 77353-35-6
ethyl 2-(prop-2-yn-1-yloxy)acetate

: 937055-44-2
ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate

: 937055-43-1
ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]acetate

Guidance literature:: In toluene; Reflux;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937055-44-2
ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate

: 937055-43-1
ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: trichlorophosphate / 20 °C / Cooling with ice

1.2: 3 h / 50 °C

2.1: toluene / 7 h / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

5.1: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: sodium azide / water; N,N-dimethyl-formamide / 6 h / 80 °C

9.1: toluene / Reflux

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; triethylamine; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1.1: Vilsmeier reaction / 1.2: Vilsmeier reaction / 2.1: Wittig reaction / 4.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937055-44-2
ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-5-yl)methoxy]-acetate

: 937055-43-1
ethyl 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]acetate

Guidance literature:: Multi-step reaction with 8 steps

1: toluene / 7 h / 100 °C

2: sodium tetrahydroborate / methanol / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

4: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

5: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6: triethylamine / dichloromethane / 3 h / 0 °C

7: sodium azide / water; N,N-dimethyl-formamide / 6 h / 80 °C

8: toluene / Reflux

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1: Wittig reaction / 3: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054