N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide

Base Information

• Chemical Name: N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide
• CAS No.: 1361952-42-2
• Molecular Formula: C₄₆H₄₇N₅O₅
• Molecular Weight: 749.91

Synonyms:N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide

Chemical Property of N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide

Chemical Property:

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Technology Process of N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide

There total 1 articles about N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-(tert-butyldimethylsilanyloxy)ethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide (1361952-41-1) → N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide (1361952-42-2)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In dichloromethane; for 10h;

Reference yield:

N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-hydroxyethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide (1361952-42-2) → 3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]-N-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}phenyl)propionamide

Guidance literature:

With hydrogen; palladium on activated carbon; In ethanol;

upstream raw materials:

N-(4-{[(R)-2-(8-benzyloxy-2-oxo-1,2-dihydroquinolin-5-yl)-2-(tert-butyldimethylsilanyloxy)ethylamino]methyl}phenyl)-3-[(S)-3-(carbamoyldiphenylmethyl)pyrrolidin-1-yl]propionamide

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