(Z)-4'-fluoro-7-hydroxy-5-heptenophenone

Base Information

Chemical Name:(Z)-4'-fluoro-7-hydroxy-5-heptenophenone
CAS No.:217454-36-9
Molecular Formula:C₁₃H₁₅FO₂
Molecular Weight:222.259
Hs Code.:

Synonyms:(Z)-4'-fluoro-7-hydroxy-5-heptenophenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-4'-fluoro-7-hydroxy-5-heptenophenone

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Technology Process of (Z)-4'-fluoro-7-hydroxy-5-heptenophenone

There total 2 articles about (Z)-4'-fluoro-7-hydroxy-5-heptenophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 217454-46-1
(Z)-7-bromo-4'-fluoro-5-heptenophenone

: (1S,2S)-1-(4-Fluoro-phenyl)-2-vinyl-cyclopentanol

: 217454-36-9
(Z)-4'-fluoro-7-hydroxy-5-heptenophenone

Guidance literature:: With indium; In tetrahydrofuran; water; for 24h;
DOI:10.1021/jo981683s

Reference yield:

: 7743-27-3
(4-cyanobutyl)triphenylphosphonium bromide

: 217454-36-9
(Z)-4'-fluoro-7-hydroxy-5-heptenophenone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KN(SiMe₃)2 / 1.) THF, toluene, 1.5 h, 2.) THF, 4 h

2: 2.) HCl / 1.) benzene, Et₂O, reflux, 15 min, 2,) H₂O, MeOH, 0 deg c to room temperature

With hydrogenchloride; potassium hexamethylsilazane;
DOI:10.1021/jo981683s