1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

Base Information

• Chemical Name: 1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine
• CAS No.: 1374260-91-9
• Molecular Formula: C₃₁H₂₅N₇
• Molecular Weight: 495.586
• Mol file: 1374260-91-9.mol

Synonyms:1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

Chemical Property of 1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine

There total 8 articles about 1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H33N7O2 (1374263-13-4) → 1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine (1374260-91-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol;

Reference yield:

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one (885-70-1) → 1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine (1374260-91-9)

Guidance literature:

Multi-step reaction with 8 steps

1: Lawessons reagent; pyridine / 18 h / 100 °C

2: 1 h / 95 °C

3: acetic acid / 13 h / 105 °C

4: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

7: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

8: hydrogenchloride / 1,4-dioxane; methanol

With Lawessons reagent; pyridine; hydrogenchloride; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium perbromide hydrobromide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

Reference yield:

5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo diazepine-6-thione (1204296-84-3) → 1-{4-[2-(1H-pyrrolo[3,2-b]pyridin-6-yl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutanamine (1374260-91-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 1 h / 95 °C

2: acetic acid / 13 h / 105 °C

3: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

5: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

6: potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

7: hydrogenchloride / 1,4-dioxane; methanol

With hydrogenchloride; potassium phosphate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium perbromide hydrobromide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

5,11-dihydro-6H-pyrido[2,3-b][1,4]benzo diazepine-6-thione

9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzo diazepine

N-(2,2-dimethoxyethyl)-11H-pyrido[2,3-b][1,4]benzodiazepin-6-amine