6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole

Base Information

Chemical Name:6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole
CAS No.:104437-26-5
Molecular Formula:C₂₄H₂₆N₆O₂
Molecular Weight:430.509
Hs Code.:

Synonyms:6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole

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Chemical Property of 6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole

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Technology Process of 6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole

There total 4 articles about 6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 104437-27-6
6-(2-cyclopentylacetamido)-1-(4-cyano-2-methoxybenzyl)indole

: 104437-26-5
6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole

Guidance literature:: With 1-methyl-pyrrolidin-2-one; sodium azide; triethylamine hydrochloride; at 150 ℃; for 3.5h;
DOI:10.1021/jm00171a018

Reference yield:

: 7151-68-0
3-methoxy-p-toluic acid

: 104437-26-5
6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / chlorosulfonyl isocyanate / CH₂Cl₂ / 0.75 h / Heating

2: 65 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 0.25 h / Heating; Irradiation

3: 1.) a) NaH / 1.) a) DMF, 0 deg C, 15 min, b) RT, 30 min, 2.) a) 0 deg C, 15 min, b) RT, 4.25 h

4: 29 percent / sodium azide, Et₃N*HCl, N-methylpyrrolidone (NMP) / 3.5 h / 150 °C

With 1-methyl-pyrrolidin-2-one; N-Bromosuccinimide; sodium azide; Perbenzoic acid; isocyanate de chlorosulfonyle; triethylamine hydrochloride; sodium hydride; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm00171a018

Reference yield:

: 3556-60-3
3-methoxy-4-methylcyano-benzene

: 104437-26-5
6-(2-cyclopentylacetamido)-1-(2-methoxy-4-[1(H)-tetrazol-5-yl]benzyl)indole

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 0.25 h / Heating; Irradiation

2: 1.) a) NaH / 1.) a) DMF, 0 deg C, 15 min, b) RT, 30 min, 2.) a) 0 deg C, 15 min, b) RT, 4.25 h

3: 29 percent / sodium azide, Et₃N*HCl, N-methylpyrrolidone (NMP) / 3.5 h / 150 °C

With 1-methyl-pyrrolidin-2-one; N-Bromosuccinimide; sodium azide; Perbenzoic acid; triethylamine hydrochloride; sodium hydride; In tetrachloromethane;
DOI:10.1021/jm00171a018