(S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride

Base Information

• Chemical Name: (S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride
• CAS No.: 1541199-19-2
• Molecular Formula: C₂₁H₂₈N₄O₃*ClH
• Molecular Weight: 420.939
• Mol file: 1541199-19-2.mol

Synonyms:(S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride

Chemical Property of (S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride

There total 10 articles about (S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate (1541259-42-0) → (S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride (1541199-19-2)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.5h; Reflux;

Reference yield:

1,3-dibromo-5-t-butylbenzene (129316-09-2) → (S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride (1541199-19-2)

Guidance literature:

Multi-step reaction with 9 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: ammonium acetate / isopropyl alcohol / 14 h / Reflux; Inert atmosphere

3.1: hydrogenchloride / 1.5 h / Reflux

4.1: water; sodium hydroxide

4.2: 20 °C / pH 8.2 / Enzymatic reaction

5.1: hydrogenchloride / 2 h / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate / N,N-dimethyl-formamide; water / 2 h / 80 °C / Inert atmosphere

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: hydrogenchloride / ethanol / 0.5 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; ammonium acetate; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium hydroxide; In diethyl ether; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 7.1: |Suzuki Coupling;

Reference yield:

(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate (1541199-18-1) → (S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate hydrochloride (1541199-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: hydrogenchloride / ethanol / 0.5 h / Reflux

With hydrogenchloride; trifluoroacetic acid; In ethanol; dichloromethane;

upstream raw materials:

(S)-ethyl 3-(2-((tert-butoxycarbonyl)amino)acetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate

(S)-ethyl 3-(2-aminoacetamido)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)propanoate

1,3-dibromo-5-t-butylbenzene

3-bromo-5-formyl-tert-butylbenzene

Downstream raw materials:

(3S)-3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

(3S)-ethyl 3-(3-(tert-butyl)-5-(pyrimidin-5-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate