4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid

Base Information

Chemical Name:4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid
CAS No.:1620147-26-3
Molecular Formula:C₂₀H₁₃F₃N₄O₃
Molecular Weight:414.343
Hs Code.:

Synonyms:4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid

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Chemical Property of 4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid

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Technology Process of 4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid

There total 6 articles about 4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1620147-25-2
methyl 4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoate

: 1620147-26-3
4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; Reflux;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 1620147-26-3
4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

2: sodium hydroxide; water / methanol / Reflux

With water; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 63200-54-4
2,4-dichloro-5H-pyrrolo[3,2-d]pyrimidine

: 1620147-26-3
4-((4-(4-(trifluoromethoxy)phenyl)-5H-pyrrolo[3,2-d]pyrimidin-2-yl)amino)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydroxide / acetone / 3 h / 20 °C

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

3: sodium hydroxide / methanol / 1 h / Reflux

4: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

5: sodium hydroxide; water / methanol / Reflux

With bis-triphenylphosphine-palladium(II) chloride; water; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium hydroxide; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetone; 2: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.066