4-(azetidin-3-yl)benzonitrile hcl

Base Information

• Chemical Name: 4-(azetidin-3-yl)benzonitrile hcl
• CAS No.: 94268-29-8
• Molecular Formula: C₁₀H₁₀N₂*ClH
• Molecular Weight: 194.664
• Mol file: 94268-29-8.mol

Synonyms:4-(azetidin-3-yl)benzonitrile hydrochloride

Chemical Property of 4-(azetidin-3-yl)benzonitrile hcl

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-(Azetidin-3-yl)benzonitrileHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(azetidin-3-yl)benzonitrile hcl

There total 2 articles about 4-(azetidin-3-yl)benzonitrile hcl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl-3-(4-cyanophenyl)azetidine-1-carboxylate → 4-(azetidin-3-yl)benzonitrile hydrochloride (94268-29-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1.5h;

Reference yield:

4-cyanophenylboronic acid (126747-14-6) → 4-(azetidin-3-yl)benzonitrile hydrochloride (94268-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trans-2-aminocyclohexanol hydrochloride; nickel(II) iodide; sodium hexamethyldisilazane / isopropyl alcohol / 0.17 h / 20 °C / Inert atmosphere

1.2: 1 h / 80 °C

2.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

With nickel(II) iodide; hydrogenchloride; trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane; In 1,4-dioxane; isopropyl alcohol;

Reference yield: 69.0%

4-(azetidin-3-yl)benzonitrile hydrochloride (94268-29-8) + 3-(3-(2-methoxyethoxy)-4-methyl-1H-pyrazol-5-yl)-4-methylbenzoic acid → C25H26N4O3

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

4-cyanophenylboronic acid

Refernces

• 1、 -. "HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS AND COMBINATIONS THEREOF". Page/Page column 85; 86. . Retrieved 2015/07/07.