Technology Process of C18H20O5
There total 1 articles about C18H20O5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; diisopropyl-carbodiimide;
In
dichloromethane;
at 0 ℃;
Inert atmosphere;
DOI:10.1016/j.tet.2011.10.073
- Guidance literature:
-
With
2,6-di-tert-butyl-4-methyl-phenol;
In
5,5-dimethyl-1,3-cyclohexadiene;
at 130 ℃;
for 48h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1016/j.tet.2011.10.073
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 2,6-di-tert-butyl-4-methyl-phenol / 5,5-dimethyl-1,3-cyclohexadiene / 48 h / 130 °C / Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere
3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere
3.2: -40 °C / Inert atmosphere
4.1: dmap; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
5.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere
6.1: lithium triethylborohydride / tetrahydrofuran / -20 - 15 °C / Inert atmosphere
With
dmap; 2,6-di-tert-butyl-4-methyl-phenol; chloroformic acid ethyl ester; lithium triethylborohydride; sodium hydrogencarbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
In
tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl-formamide;
1.1: intramolecular Diels-Alder reaction;
DOI:10.1016/j.tet.2011.10.073
