(-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate

Base Information

Chemical Name:(-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate
CAS No.:1448550-68-2
Molecular Formula:C₂₅H₂₇BrClNO₅S
Molecular Weight:568.916
Hs Code.:

Synonyms:(-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate

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Chemical Property of (-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate

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Technology Process of (-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate

There total 4 articles about (-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₉H₂₃BrClNO₅

: 106-54-7
p-Chlorothiophenol

: 1448550-68-2
(-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tetasy.2013.05.023

Reference yield:

: 139575-14-7,120672-87-9
N-(4-bromobenzylidene)glycine methyl ester

: 1448550-68-2
(-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc trifluoromethanesulfonate; triethylamine; C₂₁H₂₃FeNO / benzene; dichloromethane / 6 h / -20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / Inert atmosphere

2.2: 5 h / 5 - 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With C₂₁H₂₃FeNO; zinc trifluoromethanesulfonate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.tetasy.2013.05.023

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1448550-68-2
(-)-4-(tert-butyl) 2-methyl (2R,4R,5S)-5-(4-bromophenyl)-1-(2-((4-chlorophenyl)thio)acetyl)pyrrolidine-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: zinc trifluoromethanesulfonate; triethylamine; C₂₁H₂₃FeNO / benzene; dichloromethane / 6 h / -20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / Inert atmosphere

2.2: 5 h / 5 - 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

With C₂₁H₂₃FeNO; zinc trifluoromethanesulfonate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.tetasy.2013.05.023