Technology Process of Methanesulfonic acid (1R,3R,5R)-3-benzyloxy-5-(toluene-4-sulfonylamino)-cycloheptyl ester
There total 3 articles about Methanesulfonic acid (1R,3R,5R)-3-benzyloxy-5-(toluene-4-sulfonylamino)-cycloheptyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 77 percent / LiCl, p-benzoquinone / Pd(OAc)2 (7percent) / acetic acid
2: 77 percent / acetonitrile; dimethylsulfoxide / 3 h / 80 °C
3: 98 percent / H2 / RhCl(PPh3)3 / ethanol / 15 h / 20 °C / 4560 Torr
4: 99 percent / NaOH / methanol; H2O
5: 100 percent / Et3N / tetrahydrofuran
With
sodium hydroxide; hydrogen; triethylamine; p-benzoquinone; lithium chloride;
palladium diacetate; RhCl(PPh3)3;
In
tetrahydrofuran; methanol; ethanol; water; acetic acid; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0040-4039(00)95578-3
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 77 percent / acetonitrile; dimethylsulfoxide / 3 h / 80 °C
2: 98 percent / H2 / RhCl(PPh3)3 / ethanol / 15 h / 20 °C / 4560 Torr
3: 99 percent / NaOH / methanol; H2O
4: 100 percent / Et3N / tetrahydrofuran
With
sodium hydroxide; hydrogen; triethylamine;
RhCl(PPh3)3;
In
tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0040-4039(00)95578-3
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 99 percent / NaOH / methanol; H2O
2: 100 percent / Et3N / tetrahydrofuran
With
sodium hydroxide; triethylamine;
In
tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)95578-3
