[3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester

Base Information

Chemical Name:[3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester
CAS No.:216491-39-3
Molecular Formula:C₂₈H₃₀NO₆P
Molecular Weight:507.523
Hs Code.:

Synonyms:[3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester

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Chemical Property of [3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester

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Technology Process of [3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester

There total 7 articles about [3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1700-30-7
(3-(benzyloxy)phenyl)methanol

: 216491-39-3
[3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: PBr₃ / toluene / 0.17 h / 100 °C

2: 1.) LHMDS / 1.) THF, -78 deg C, 45 min, 2.) THF, from -78 deg C to RT, overnight

3: H₂ / Pd/C / ethanol / Ambient temperature

4: Et₃N, DMAP / CH₂Cl₂ / -78 - 20 °C

5: Pd(PPh₃)4, Et₃N / 4 h / 110 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; phosphorus tribromide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In ethanol; dichloromethane; toluene;
DOI:10.1016/S0960-894X(98)00409-0

Reference yield:

: 1700-31-8
3-benzyloxybenzyl bromide

: 216491-39-3
[3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LHMDS / 1.) THF, -78 deg C, 45 min, 2.) THF, from -78 deg C to RT, overnight

2: H₂ / Pd/C / ethanol / Ambient temperature

3: Et₃N, DMAP / CH₂Cl₂ / -78 - 20 °C

4: Pd(PPh₃)4, Et₃N / 4 h / 110 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00409-0

Reference yield:

: 620-24-6
3-Hydroxybenzyl alcohol

: 216491-39-3
[3-((2R,4S)-3-Benzoyl-4-methyl-5-oxo-2-phenyl-oxazolidin-4-ylmethyl)-phenyl]-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH / methanol / Ambient temperature

2: PBr₃ / toluene / 0.17 h / 100 °C

3: 1.) LHMDS / 1.) THF, -78 deg C, 45 min, 2.) THF, from -78 deg C to RT, overnight

4: H₂ / Pd/C / ethanol / Ambient temperature

5: Et₃N, DMAP / CH₂Cl₂ / -78 - 20 °C

6: Pd(PPh₃)4, Et₃N / 4 h / 110 °C

With dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; phosphorus tribromide; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/S0960-894X(98)00409-0