1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Base Information

Chemical Name:1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea
CAS No.:1429340-09-9
Molecular Formula:C₃₈H₄₂FN₅O₇S
Molecular Weight:731.845
Hs Code.:

Synonyms:1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Chemical Property of 1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

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Technology Process of 1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

There total 4 articles about 1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.4%

: 1187213-95-1
1-cyclopropyl-3-(3-fluoro-4-(2-(5-formylpyridin-2-yl)thieno[3,2-b]-pyridin-7-yloxy)phenyl)urea

: 1429340-31-7
2-(2.5.8.11-tetraoxatridecan-13-yloxy)aniline

: 1429340-09-9
1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: With phenylsilane; dibutyltin chloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: 128134-66-7
1-methoxy-11-(2'-nitrophenoxy)-3,6,9-trioxaundecane

: 1429340-09-9
1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; ammonium chloride / water; methanol / 1 h / Reflux

2: dibutyltin chloride; phenylsilane / N,N-dimethyl-formamide; tetrahydrofuran / 48 h / 20 °C

With phenylsilane; dibutyltin chloride; ammonium chloride; zinc; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 23783-42-8,95507-80-5
tetraethylene glycol monomethyl ether

: 1429340-09-9
1-(4-(2-(5-((2-(2,5.8,11-tetraoxatridecan-13-yloxy)phenylamino)methyl)pyridin-2-yl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenyl)-3-cyclopropylurea

Guidance literature:: Multi-step reaction with 3 steps

1: N-benzyl-N,N,N-triethylammonium chloride / toluene / 20 h / Reflux

2: zinc; ammonium chloride / water; methanol / 1 h / Reflux

3: dibutyltin chloride; phenylsilane / N,N-dimethyl-formamide; tetrahydrofuran / 48 h / 20 °C

With phenylsilane; dibutyltin chloride; N-benzyl-N,N,N-triethylammonium chloride; ammonium chloride; zinc; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;