4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

Base Information

Chemical Name:4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid
CAS No.:1416581-40-2
Molecular Formula:C₂₇H₂₆F₄N₂O₅
Molecular Weight:534.507
Hs Code.:

4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

Synonyms:4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

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Technology Process of 4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

There total 13 articles about 4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: ethyl 4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoate

: 1416581-40-2
4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.8b00145

Reference yield:

: C₁₇H₂₀FNO₃

: 1416581-40-2
4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: OJ-H / isopropyl alcohol / Resolution of racemate; Inert atmosphere

2: titanium(IV) tetraethanolate / tetrahydrofuran / 80 °C / Inert atmosphere

3: methanol; sodium tetrahydroborate / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

6: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

7: sodium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C / Inert atmosphere

With methanol; dmap; titanium(IV) tetraethanolate; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/acsmedchemlett.8b00145

Reference yield:

: 1416585-31-3
tert-butyl (3aS,9aR)-7-fluoro-9-oxo-1,2,3,3a,9,9a-hexahydro-4H-cyclopenta[b]quinoline-4-carboxylate

: 1416581-40-2
4-(cyclopropyl((3aS,9R,9aR)-7-fluoro-4-(4-(trifluoromethoxy)benzoyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]quinolin-9-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 80 °C / Inert atmosphere

2: methanol; sodium tetrahydroborate / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

5: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

6: sodium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C / Inert atmosphere

With methanol; dmap; titanium(IV) tetraethanolate; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/acsmedchemlett.8b00145